Elucidating mechanisms at the nano-bio interface to inform next-generation antimicrobial design
Several inorganic materials are widely used for their antimicrobial properties. Two that we investigate are silver and copper. Manipulating these elements in nano-scale materials introduces unique properties and mechanisms of interaction with microorganisms. The aim of our research is to uncover underlying mechanisms of these interactions and link them to specific nanomaterial properties so that we can tune behavior for specific applications. We are particularly interested in approaching this research through the lens of antimicrobial resistance, the need to develop effective alternative antimicrobials, and the potential for nano-enable solutions to tackle this global challenge.
Watch our group at work! (click the above image) (Video by Pisano Films | Soundtrack by DJ Thermos |www.pisanofilms.com)
Read more about our work in this area:
Stabryla, L. M.*; Johnston, K. A.; Diemler, N. A.; Millstone, J. E.; Haig, S. J.; Gilbertson, L. M.* “Role of bacterial motility in differential resistance mechanisms 1of silver nanoparticles and silver ions.” Nature Nanotechnology, 10.1038/s41565-021-00929-w
Albalghiti, E.; Stabryla, L. M.; Gilbertson, L. M.; Zimmerman, J. B.* “Towards resolution of antibacterial mechanisms in metal and metal oxide nanomaterials: a meta-analysis of the influence of study design on mechanistic conclusions.” Environmental Science: Nano, 2021, 8, 37-66.
Johnston, K. A.; Stabryla, L. M.; Gilbertson, L. M.; Millstone, J. E. “Connecting Concepts of Coinage Metal Stability Across Length Scales.” Environmental Science: Nano, 2019, 6, 2674-2696
Stabryla, L.; Johnston, K.; Millstone, J. E.; Gilbertson, L. M. “It’s Not All About the Ion!: Evidence for Particle-Specific Contributions to AgNP Antimicrobial Activity.” Environmental Science: Nano, Emerging Investigator Series, 2018, Advance Article, DOI: 10.1039/C8EN00429C
Johnston, K. A.; Stabryla, L. M.; Smith, A. M.; Gan, X. Y.; Gilbertson, L. M.; Millstone, J. E. "Impacts of Broth Chemistry on Silver Ion Release, Surface Chemistry Composition, and Bacterial Cytotoxicity of Silver Nanoparticles." Environmental Science: Nano, 2018, DOI: 10.1039/C7EN00974G Gilbertson, L. M.; Albalghiti, E. M.; Fishman, Z. S.; Perreault, F.; Corredor, C.; Posner, J. D.; Elimelech, M.; Pfefferle, L. D.; Zimmerman, J. B. "Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide". Environmental Science and Technology, 2016, 50(7), 3975-3984. DOI: 10.1021/acs.est.5b05734
This research is made possible through generous support from:
CBET No: 1935378 Looking for the silver lining: Assessing the impact of silver in showerheads on opportunistic pathogen abundance and resistance